When evil wizards Razamel and Gargamel take Papa Smurf, the Smurfs embark on a mission to the real world to save him. With help from some new friends, they must discover what defines their destiny to save the universe.

Five years after the events of Dominion, a covert team led by Zora Bennett (Scarlett Johansson), paleo expert Henry Loomis (Jonathan Bailey), and Duncan Kincaid (Mahershala Ali) is dispatched to a remote island to collect genetic samples from the planet?s three largest prehistoric species and, sea, and air to unlock a groundbreaking medical cure